Multiple treatment comparisons in epilepsy monotherapy trials.

ABSTRACT:

Background

The choice of antiepileptic drug for an individual should be based upon the highest quality evidence regarding potential benefits and harms of the available treatments. Systematic reviews and meta-analysis of randomised controlled trials should be a major source of evidence supporting this decision making process. We summarise all available individual patient data evidence from randomised controlled trials that compared at least two out of eight antiepileptic drugs given as monotherapy.

Methods

Multiple treatment comparisons from epilepsy monotherapy trials were synthesized in a single stratified Cox regression model adjusted for treatment by epilepsy type interactions and making use of direct and indirect evidence. Primary outcomes were time to treatment failure

SUBMITTER: Tudur Smith C 

PROVIDER: S-EPMC2194733 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature