CoryneRegNet 4.0 - A reference database for corynebacterial gene regulatory networks.

ABSTRACT:

Background

Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression) and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions and global DNA microarray hybridization experiments, has opened the way for the genome-wide analysis of transcriptional regulatory networks. The large-scale reconstruction of these networks allows the in silico analysis of cell behavior in response to changing environmental conditions. We previously published CoryneRegNet, an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. Initially, it was designed to provide methods for the analysis and visualization of the gene regulatory network of

SUBMITTER: Baumbach J 

PROVIDER: S-EPMC2194740 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature