Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

ABSTRACT: A key molecule necessary for activation of T lymphocytes through their antigen-specific T cell receptor (TCR) is the transmembrane adaptor protein LAT (linker for activation of T cells). Upon TCR engagement, LAT becomes rapidly tyrosine phosphorylated and then serves as a scaffold organizing a multicomponent complex that is indispensable for induction of further downstream steps of the signaling cascade. Here we describe the identification and preliminary characterization of a novel transmembrane adaptor protein that is structurally and evolutionarily related to LAT and is expressed in B lymphocytes, natural killer (NK) cells, monocytes, and mast cells but not in resting T lymphocytes. This novel transmembrane adaptor protein, termed NTAL (non-T cell activation linker) is the product of a

SUBMITTER: Brdicka T 

PROVIDER: S-EPMC2196071 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature