Does the effectiveness of control measures depend on the influenza pandemic profile?

ABSTRACT:

Background

Although strategies to contain influenza pandemics are well studied, the characterization and the implications of different geographical and temporal diffusion patterns of the pandemic have been given less attention.

Methodology/main findings

Using a well-documented metapopulation model incorporating air travel between 52 major world cities, we identified potential influenza pandemic diffusion profiles and examined how the impact of interventions might be affected by this heterogeneity. Clustering methods applied to a set of pandemic simulations, characterized by seven parameters related to the conditions of emergence that were varied following Latin hypercube sampling, were used to identify six pandemic profiles exhibiting different characteristics notably in ter

SUBMITTER: Kerneis S 

PROVIDER: S-EPMC2198944 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature