Synthesis of the benzo-fused indolizidine alkaloid mimics.

ABSTRACT: A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation.

SUBMITTER: Comins DL 

PROVIDER: S-EPMC2200666 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature