Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.

ABSTRACT: SET domain-containing proteins represent an evolutionarily conserved family of epigenetic regulators, which are responsible for most histone lysine methylation. Since some of these genes have been revealed to be essential for embryonic development, we propose that the zebrafish, a vertebrate model organism possessing many advantages for developmental studies, can be utilized to study the biological functions of these genes and the related epigenetic mechanisms during early development. To this end, we have performed a genome-wide survey of zebrafish SET domain genes. 58 genes total have been identified. Although gene duplication events give rise to several lineage-specific paralogs, clear reciprocal orthologous relationship reveals high conservation between zebrafish and human SET domain g

SUBMITTER: Sun XJ 

PROVIDER: S-EPMC2200798 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature