Candidate markers for the detection of hepatocellular carcinoma in low-molecular weight fraction of serum.

ABSTRACT: Hepatocellular carcinoma (HCC) represents an important public health problem in Egypt where up to 90% of HCC cases are attributable to hepatitis C viral (HCV) infection. Serum alpha-fetoprotein is elevated in only approximately 60% of HCC patients. The development of effective markers for the detection of HCC could have an impact on cancer mortality and significant public health implications worldwide. The objective of our study was to assess six candidate markers for detection of HCC identified by mass spectrometric analysis of enriched serum. The study examined 78 HCC cases and 72 age- and gender-matched cancer-free controls recruited from the Egyptian population. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometric analysis of enriched low-molecular weight fract

SUBMITTER: Goldman R 

PROVIDER: S-EPMC2204039 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature