Prediction of death and prolonged mechanical ventilation in acute lung injury.

ABSTRACT:

Introduction

Prediction of death and prolonged mechanical ventilation is important in terms of projecting resource utilization and in establishing protocols for clinical studies of acute lung injury (ALI). We aimed to identify risk factors for a combined end-point of death and/or prolonged ventilator dependence and developed an ALI-specific prediction model.

Methods

In this retrospective analysis of three multicenter clinical studies, we identified predictors of death or ventilator dependence from variables prospectively recorded during the first three days of mechanical ventilation. After the prediction model was derived in an international cohort of patients with ALI, it was validated in two independent samples of patients enrolled in a clinical trial involving 17 academic

SUBMITTER: Gajic O 

PROVIDER: S-EPMC2206401 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature