Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.

ABSTRACT: Glucocorticoid-induced TNF receptor ligand (GITRL), a recently identified member of the TNF superfamily, binds to its receptor, GITR, on both effector and regulatory T cells and generates positive costimulatory signals implicated in a wide range of T cell functions. In contrast to all previously characterized homotrimeric TNF family members, the mouse GITRL crystal structure reveals a previously unrecognized dimeric assembly that is stabilized via a unique "domain-swapping" interaction. Consistent with its crystal structure, mouse GITRL exists as a stable dimer in solution. Structure-guided mutagenesis studies confirmed the determinants responsible for dimerization and support a previously unrecognized receptor-recognition surface for mouse GITRL that has not been observed for any other TN

SUBMITTER: Chattopadhyay K 

PROVIDER: S-EPMC2206588 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature