Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.

ABSTRACT:

Background

The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive.

Methodology

To define the role of ss-catenin signaling in these processes, we used a Dermo1(Twist2)(Cre/+) line to target a floxed beta-catenin allele, throughout the embryonic mesenchyme. Strikingly, the Dermo1(Cre/+); beta-catenin(f/-) conditional Knock Out embryos largely phenocopy Pitx1(-/-)/Pitx2(-/-) double knockout embryos, suggesting that ss-catenin signaling in the mesenchyme depends mostly on the PITX family of transcription factors. We have dissected this relationship further in the developing lungs and find that mesenchymal deletion of beta-catenin differentially affects two major mesenchymal lineages. The amplification but not differentiation of Fgf1

SUBMITTER: De Langhe SP 

PROVIDER: S-EPMC2211394 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature