Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils.

ABSTRACT: The movement of leukocytes into tissues is regulated by the local production of chemical mediators collectively referred to as chemoattractants. Although chemoattractants constitute a diverse array of molecules, including proteins, peptides, and lipids, they all appear to signal leukocytes through a related family of seven transmembrane-spanning G protein-coupled receptors. The eosinophil is a potent proinflammatory cell that is attracted into tissues during allergic inflammation, parasitic infection, and certain malignancies. Since the molecular mechanisms controlling eosinophil recruitment are incompletely understood, we performed a degenerate polymerase chain reaction on cDNA isolated from murine eosinophils to identify novel chemoattractant receptors. We report the isolation of a cDNA

SUBMITTER: Huang WW 

PROVIDER: S-EPMC2212531 | biostudies-literature | 1998 Sep

REPOSITORIES: biostudies-literature