Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris.

ABSTRACT:

Background

Acne vulgaris afflicts more than fifty million people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P. acnes using antibiotics, or target the follicle with retinoids such as isotretinoin. The latter systemic treatment is highly effective but also carries a risk of side effects including immune imbalance, hyperlipidemia, and teratogenicity. Despite substantial research into potential new therapies for this common disease, vaccines against acne vulgaris are not yet available.

Methods and findings

Here we create an acne vaccine targeting a cell wall-anchored sialidase of P. acnes. The importance of sialidase to disease pathogenesis is shown by trea

SUBMITTER: Nakatsuji T 

PROVIDER: S-EPMC2212713 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature