The PYRIN connection: novel players in innate immunity and inflammation.

ABSTRACT: Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.

SUBMITTER: Stehlik C 

PROVIDER: S-EPMC2212741 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature