Ontology highlight
ABSTRACT:
SUBMITTER: Walmsley SR
PROVIDER: S-EPMC2212759 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20050101 1
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These inflammatory sites are characterized by low levels of oxygen and glucose and high levels of reductive metabolites. A major regulator of neutrophil functional longevity is the ability of these cells to undergo apoptosis. We examined the mechanism by which hypoxia causes an inhibition of neutrophil apoptosis in human and murine neutrophils. W ...[more]