Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

ABSTRACT: We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their

SUBMITTER: ENCODE Project Consortium 

PROVIDER: S-EPMC2212820 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature