Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease.

ABSTRACT:

Background

Bovine tuberculosis is an enduring disease of cattle that has significant repercussions for human health. The advent of high-throughput functional genomics technologies has facilitated large-scale analyses of the immune response to this disease that may ultimately lead to novel diagnostics and therapeutic targets. Analysis of mRNA abundance in peripheral blood mononuclear cells (PBMC) from six Mycobacterium bovis infected cattle and six non-infected controls was performed. A targeted immunospecific bovine cDNA microarray with duplicated spot features representing 1,391 genes was used to test the hypothesis that a distinct gene expression profile may exist in M. bovis infected animals in vivo.

Results

In total, 378 gene features were differentially expressed at the

SUBMITTER: Meade KG 

PROVIDER: S-EPMC2213678 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature