Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis.

ABSTRACT:

Objective

To determine if there is a relation between aspirin "resistance" and clinical outcomes in patients with cardiovascular disease.

Design

Systematic review and meta-analysis.

Data source

Electronic literature search without language restrictions of four databases and hand search of bibliographies for other relevant articles.

Review methods

Inclusion criteria included a test for platelet responsiveness and clinical outcomes. Aspirin resistance was assessed, using a variety of platelet function assays.

Results

20 studies totalling 2930 patients with cardiovascular disease were identified. Most studies used aspirin regimens, ranging from 75-325 mg daily, and six studies included adjunct antiplatelet therapy. Compliance was confirmed directly in 14 st

SUBMITTER: Krasopoulos G 

PROVIDER: S-EPMC2213873 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature