IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes.

ABSTRACT: In osteoarthritis (OA), cartilage destruction is associated not only with an imbalance of anabolic and catabolic processes but also with alterations of the cytoskeletal organization in chondrocytes, although their pathogenetic origin is largely unknown so far. Therefore, we have studied possible effects of the proinflammatory cytokine IL-1beta on components of the cytoskeleton in OA chondrocytes on gene expression level. Using a whole genome array, we found that IL-1beta is involved in the regulation of many cytoskeleton-related genes. Apart from well-known cytoskeletal components, the expression and regulation of four genes coding for LIM proteins were shown. These four genes were previously undescribed in the chondrocyte context. Quantitative PCR analysis confirmed significant downregula

SUBMITTER: Joos H 

PROVIDER: S-EPMC2213891 | biostudies-literature | 2008 Mar-Apr

REPOSITORIES: biostudies-literature