Global dynamics of newly constructed oligonucleosomes of conventional and variant H2A.Z histone.

ABSTRACT:

Background

Complexes of nucleosomes, which often occur in the gene promoter areas, are one of the fundamental levels of chromatin organization and thus are important for transcription regulation. Investigating the dynamic structure of a single nucleosome as well as nucleosome complexes is important for understanding transcription within chromatin. In a previous work, we highlighted the influence of histone variants on the functional dynamics of a single nucleosome using normal mode analysis developed by Bahar et al. The present work further analyzes the dynamics of nucleosome complexes (nucleosome oligomers or oligonucleosomes) such as dimer, trimer and tetramer (beads on a string model) with conventional core histones as well as with the H2A.Z histone variant using normal mode ana

SUBMITTER: Ramaswamy A 

PROVIDER: S-EPMC2216022 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature