Reduced modeling of signal transduction - a modular approach.

ABSTRACT:

Background

Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively and a lot of progress has been made within the last few years. A software tool (BioNetGen) was developed which allows an automatic rule-based set-up of mechanistic model equations. In many cases these models can be reduced by an exact domain-oriented lumping technique. However, the resulting models can still consist of a very large number of differential equations.

Results

We introduce a new reduction technique, which allows building modularized and highly reduced models. Compared to existing approaches further reduction of signal transduction networks is possible. The method also provides a new mod

SUBMITTER: Koschorreck M 

PROVIDER: S-EPMC2216040 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature