Identification of novel light-induced genes in the suprachiasmatic nucleus.

ABSTRACT:

Background

The transmission of information about the photic environment to the circadian clock involves a complex array of neurotransmitters, receptors, and second messenger systems. Exposure of an animal to light during the subjective night initiates rapid transcription of a number of immediate-early genes in the suprachiasmatic nucleus of the hypothalamus. Some of these genes have known roles in entraining the circadian clock, while others have unknown functions. Using laser capture microscopy, microarray analysis, and quantitative real-time PCR, we performed a comprehensive screen for changes in gene expression immediately following a 30 minute light pulse in suprachiasmatic nucleus of mice.

Results

The results of the microarray screen successfully identified previously k

SUBMITTER: Porterfield VM 

PROVIDER: S-EPMC2216081 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature