Ontology highlight
ABSTRACT:
SUBMITTER: Lindqvist L
PROVIDER: S-EPMC2216682 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
PloS one 20080213 2
RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected helicases a challenging problem. The prototypical DEAD box RNA helicase, eIF4A, works in conjunction with other translation factors to prepare mRNA templates for ribosome recruitment during translation initiation. Herein, we provide insight into ...[more]