Protein function assignment through mining cross-species protein-protein interactions.

ABSTRACT:

Background

As we move into the post genome-sequencing era, an immediate challenge is how to make best use of the large amount of high-throughput experimental data to assign functions to currently uncharacterized proteins. We here describe CSIDOP, a new method for protein function assignment based on shared interacting domain patterns extracted from cross-species protein-protein interaction data.

Methodology/principal findings

The proposed method is assessed both biologically and statistically over the genome of H. sapiens. The CSIDOP method is capable of making protein function prediction with accuracy of 95.42% using 2,972 gene ontology (GO) functional categories. In addition, we are able to assign novel functional annotations for 181 previously uncharacterized proteins in

SUBMITTER: Chen XW 

PROVIDER: S-EPMC2216687 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature