Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men.

ABSTRACT: The human genome encodes a limited number of genes yet contributes to individual differences in a vast array of heritable traits. A possible explanation for the capacity our genome to generate this virtually unlimited range of phenotypic variation in complex traits is to assume functional interactions between genes. Therefore we searched two mammalian genomes to identify potential epistatic interactions by looking for co-adapted genes marked by excess two-locus genetic differentiation between populations/lineages using publicly available SNP genotype data. The practical motivation for this effort is to reduce the number of pair-wise tests that need to be performed in genome-wide association studies aimed at detecting GxG interactions, by focusing on pairs predicted to be more likely to joi

SUBMITTER: Bochdanovits Z 

PROVIDER: S-EPMC2217631 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature