Individual retinal progenitor cells display extensive heterogeneity of gene expression.

ABSTRACT: The development of complex tissues requires that mitotic progenitor cells integrate information from the environment. The highly varied outcomes of such integration processes undoubtedly depend at least in part upon variations among the gene expression programs of individual progenitor cells. To date, there has not been a comprehensive examination of these differences among progenitor cells of a particular tissue. Here, we used comprehensive gene expression profiling to define these differences among individual progenitor cells of the vertebrate retina. Retinal progenitor cells (RPCs) have been shown by lineage analysis to be multipotent throughout development and to produce distinct types of daughter cells in a temporal, conserved order. A total of 42 single RPCs were profiled on Affymetr

SUBMITTER: Trimarchi JM 

PROVIDER: S-EPMC2220035 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature