Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea.

ABSTRACT:

Background

An evolutionary classification of genes from sequenced genomes that distinguishes between orthologs and paralogs is indispensable for genome annotation and evolutionary reconstruction. Shortly after multiple genome sequences of bacteria, archaea, and unicellular eukaryotes became available, an attempt on such a classification was implemented in Clusters of Orthologous Groups of proteins (COGs). Rapid accumulation of genome sequences creates opportunities for refining COGs but also represents a challenge because of error amplification. One of the practical strategies involves construction of refined COGs for phylogenetically compact subsets of genomes.

Results

New Archaeal Clusters of Orthologous Genes (arCOGs) were constructed for 41 archaeal genomes (13 Crenarcha

SUBMITTER: Makarova KS 

PROVIDER: S-EPMC2222616 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature