Analysis on multi-domain cooperation for predicting protein-protein interactions.

ABSTRACT:

Background

Domains are the basic functional units of proteins. It is believed that protein-protein interactions are realized through domain interactions. Revealing multi-domain cooperation can provide deep insights into the essential mechanism of protein-protein interactions at the domain level and be further exploited to improve the accuracy of protein interaction prediction.

Results

In this paper, we aim to identify cooperative domains for protein interactions by extending two-domain interactions to multi-domain interactions. Based on the high-throughput experimental data from multiple organisms with different reliabilities, the interactions of domains were inferred by a Linear Programming algorithm with Multi-domain pairs (LPM) and an Association Probabilistic Method with

SUBMITTER: Wang RS 

PROVIDER: S-EPMC2222654 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature