Analysis and prediction of functionally important sites in proteins.

ABSTRACT: The rapidly increasing volume of sequence and structure information available for proteins poses the daunting task of determining their functional importance. Computational methods can prove to be very useful in understanding and characterizing the biochemical and evolutionary information contained in this wealth of data, particularly at functionally important sites. Therefore, we perform a detailed survey of compositional and evolutionary constraints at the molecular and biological function level for a large set of known functionally important sites extracted from a wide range of protein families. We compare the degree of conservation across different functional categories and provide detailed statistical insight to decipher the varying evolutionary constraints at functionally important s

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC2222836 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature