Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury.

ABSTRACT:

Background

Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role of p38 mitogen-activated protein kinase/mitogen activated protein kinase kinase-3 and c-Jun-NH(2)-terminal kinase-1 in ventilator-induced lung injury and investigate novel independent mechanisms contributing to lung injury during mechanical ventilation.

Methodology and principle findings

C57/BL6 wild-type mice and mice genetically deleted for mitogen-activated protein kinase kinase-3 (mkk-3(-/-)) or c-Jun-NH(2)-terminal kinase-1 (jnk1(-/-)) were ventilated, and lung injury parameters were assessed. We demonstrate

SUBMITTER: Dolinay T 

PROVIDER: S-EPMC2223071 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature