Role of stress response sigma factor SigG in Mycobacterium tuberculosis.

ABSTRACT: The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A DeltasigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

SUBMITTER: Lee JH 

PROVIDER: S-EPMC2223564 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature