Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation.

ABSTRACT: The saeRS two-component regulatory system regulates transcription of multiple virulence factors in Staphylococcus aureus. In the present study, we demonstrated that the saePQRS region in Staphylococcus epidermidis is transcriptionally regulated in a temporal manner and is arranged in a manner similar to that previously described for S. aureus. Studies using a mouse foreign body infection model demonstrated that the virulence of strain 1457 and the virulence of a mutant, strain 1457 saeR, were statistically equivalent. However, histological analyses suggested that the polymorphonuclear neutrophil response at 2 days postinfection was significantly greater in 1457-infected mice than in 1457 saeR-infected mice, demonstrating that SaeR influences the early, acute phases of infection. Microarray

SUBMITTER: Handke LD 

PROVIDER: S-EPMC2223648 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature