In vivo efficacy of human immunodeficiency virus neutralizing antibodies: estimates for protective titers.

ABSTRACT: The definition of plasma neutralizing antibody titers capable of controlling human immunodeficiency virus (HIV) infection in vivo is considered a critical step in vaccine development. Here we provide estimates for effective neutralization titers by assessing samples from a recent passive immunization trial with the neutralizing monoclonal antibodies (MAbs) 2G12, 2F5, and 4E10 using an analytic strategy that dissects the contributions of these MAbs to the total neutralization activity in patient plasma. Assessment of neutralization activities for six responding patients with partial or complete control of viremia during the MAb treatment and for the eight nonresponding patients revealed a significant difference between these groups: Among responders, MAb-mediated activity exceeded the autol

SUBMITTER: Trkola A 

PROVIDER: S-EPMC2224433 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature