In vitro capability of faropenem to select for resistant mutants of Streptococcus pneumoniae and Haemophilus influenzae.

ABSTRACT: When tested against nine strains of pneumococci and six of Haemophilus influenzae of various resistotypes, faropenem failed to select for resistant mutants after 50 days of consecutive subculture in subinhibitory concentrations. Faropenem also yielded low rates of spontaneous mutations against all organisms of both species. By comparison, resistant clones were obtained with macrolides, ketolides, and quinolones.

SUBMITTER: Kosowska-Shick K 

PROVIDER: S-EPMC2224784 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature