Gene regulatory networks in lactation: identification of global principles using bioinformatics.

ABSTRACT:

Background

The molecular events underlying mammary development during pregnancy, lactation, and involution are incompletely understood.

Results

Mammary gland microarray data, cellular localization data, protein-protein interactions, and literature-mined genes were integrated and analyzed using statistics, principal component analysis, gene ontology analysis, pathway analysis, and network analysis to identify global biological principles that govern molecular events during pregnancy, lactation, and involution.

Conclusion

Several key principles were derived: (1) nearly a third of the transcriptome fluctuates to build, run, and disassemble the lactation apparatus; (2) genes encoding the secretory machinery are transcribed prior to lactation; (3) the diversity of the endo

SUBMITTER: Lemay DG 

PROVIDER: S-EPMC2225983 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature