Molecular organization of the olfactory septal organ.

ABSTRACT: The septal organ in the mammalian nose is a distinct chemosensory organ sitting in the air path. To gain insights into its organization and function, we analyzed the chemoreceptors expressed in this area. By combining cDNA cloning, Affymetrix (Santa Clara, CA) genechips covering all the mouse olfactory receptor genes, and in situ hybridization, we achieved a relatively complete expression profile of the olfactory receptor genes in the septal organ. The majority of the septal neurons express only a few receptor genes in varying patterns, with the top one in approximately 50% of the cells and the top eight together in approximately 93% of the cells. We demonstrated that a single neuron expresses only one receptor by a thorough combination of all the major septal receptor genes in double-labe

SUBMITTER: Tian H 

PROVIDER: S-EPMC2227317 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature