Relationship of SARS-CoV to other pathogenic RNA viruses explored by tetranucleotide usage profiling.

ABSTRACT:

Background

The exact origin of the cause of the Severe Acute Respiratory Syndrome (SARS) is still an open question. The genomic sequence relationship of SARS-CoV with 30 different single-stranded RNA (ssRNA) viruses of various families was studied using two non-standard approaches. Both approaches began with the vectorial profiling of the tetra-nucleotide usage pattern V for each virus. In approach one, a distance measure of a vector V, based on correlation coefficient was devised to construct a relationship tree by the neighbor-joining algorithm. In approach two, a multivariate factor analysis was performed to derive the embedded tetra-nucleotide usage patterns. These patterns were subsequently used to classify the selected viruses.

Results

Both approaches yielded relations

SUBMITTER: Yap YL 

PROVIDER: S-EPMC222961 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature