An improved probability mapping approach to assess genome mosaicism.

ABSTRACT:

Background

Maximum likelihood and posterior probability mapping are useful visualization techniques that are used to ascertain the mosaic nature of prokaryotic genomes. However, posterior probabilities, especially when calculated for four-taxon cases, tend to overestimate the support for tree topologies. Furthermore, because of poor taxon sampling four-taxon analyses suffer from sensitivity to the long branch attraction artifact. Here we extend the probability mapping approach by improving taxon sampling of the analyzed datasets, and by using bootstrap support values, a more conservative tool to assess reliability.

Results

Quartets of orthologous proteins were complemented with homologs from selected reference genomes. The mapping of bootstrap support values from these exten

SUBMITTER: Zhaxybayeva O 

PROVIDER: S-EPMC222983 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature