H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.

ABSTRACT:

Background

Protein tyrosine kinases play an important role in cellular metabolism as key components of signal transduction pathways. They are involved in cellular growth, differentiation, and development. Receptor tyrosine kinases (EGF receptor and c-erbB2) have been shown to be important in the pathogenesis of cancer. In ovarian cancer, overexpression of c-erbB2, a type I receptor, has been correlated with an adverse effect on survival of patients.

Material and methods

An unusual receptor tyrosine kinase, H-RYK, has been isolated from a complimentary DNA library of SKOV-3, an epithelial ovarian cancer cell line, using a polymerase chain reaction-mediated approach.

Results

The primary structure of the predicted amino acid sequence of the protein shows a novel NH2-term

SUBMITTER: Wang XC 

PROVIDER: S-EPMC2230112 | biostudies-literature | 1996 Mar

REPOSITORIES: biostudies-literature