Comparative transcriptomics in Yersinia pestis: a global view of environmental modulation of gene expression.

ABSTRACT:

Background

Environmental modulation of gene expression in Yersinia pestis is critical for its life style and pathogenesis. Using cDNA microarray technology, we have analyzed the global gene expression of this deadly pathogen when grown under different stress conditions in vitro.

Results

To provide us with a comprehensive view of environmental modulation of global gene expression in Y. pestis, we have analyzed the gene expression profiles of 25 different stress conditions. Almost all known virulence genes of Y. pestis were differentially regulated under multiple environmental perturbations. Clustering enabled us to functionally classify co-expressed genes, including some uncharacterized genes. Collections of operons were predicted from the microarray data, and some of these w

SUBMITTER: Han Y 

PROVIDER: S-EPMC2231364 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature