Cadherin-mediated adhesion regulates posterior body formation.

ABSTRACT:

Background

The anterior-posterior axis of the vertebrate embryo undergoes a dramatic elongation during early development. Convergence and extension of the mesoderm, occurring during gastrulation, initiates the narrowing and lengthening of the embryo. However the lengthening of the axis continues during post-gastrula stages in the tailbud region, and is thought to involve convergent extension movements as well as other cell behaviors specific to posterior regions.

Results

We demonstrate here, using a semi-dominant N-cadherin allele, that members of the classical cadherin subfamily of cell-cell adhesion molecules are required for tailbud elongation in the zebrafish. In vivo imaging of cell behaviors suggests that the extension of posterior axial mesodermal cells is impaired in

SUBMITTER: Harrington MJ 

PROVIDER: S-EPMC2231375 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature