Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.

ABSTRACT:

Background

Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes.

Results

Genome-wide analysis of exonization of transposed elements revealed a higher rate of exonization within duplicated genes relative to single-copy genes. The gene for TIF-IA, an RNA polymerase I transcription initiation factor, underwent a humanoid-specific triplication, all three copies of the gene are active transcriptionally, although only one copy retains the ability to generate the TIF-IA protein. Prior to TIF-IA triplication, an Alu element was inserted into the first intron. In one of the non-protein codin

SUBMITTER: Amit M 

PROVIDER: S-EPMC2231382 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature