Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.

ABSTRACT: The Notch and Epidermal Growth Factor Receptor (EGFR) signaling pathways interact cooperatively and antagonistically to regulate many aspects of Drosophila development, including the eye. How output from these two signaling networks is fine-tuned to achieve the precise balance needed for specific inductive interactions and patterning events remains an open and important question. Previously, we reported that the gene split ends (spen) functions within or parallel to the EGFR pathway during midline glial cell development in the embryonic central nervous system. Here, we report that the cellular defects caused by loss of spen function in the developing eye imaginal disc place spen as both an antagonist of the Notch pathway and a positive contributor to EGFR signaling during retinal cell diff

SUBMITTER: Doroquez DB 

PROVIDER: S-EPMC2231642 | biostudies-literature | 2007 Sep-Oct

REPOSITORIES: biostudies-literature