Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator.

ABSTRACT:

Background

Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, NCU-G1.

Results

NCU-G1 was found to be a highly conserved nuclear protein rich in proline with a molecular weight of approximately 44 kDa. It is localized on chromosome 1 and consists of 6 exons. Analysis of the amino acid sequence revealed no known transcription activation domains or DNA binding regions, however, four nuclear receptor boxes (LXXLL), and four SH3-interaction motives in addition to numerous potential phosphorylation sites were found. Two nuclear export signals were identified, but no nuclear localization signal. In man, NCU-G1 was found to be widely express

SUBMITTER: Steffensen KR 

PROVIDER: S-EPMC2233640 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature