The topology of metabolic isotope labeling networks.

ABSTRACT:

Background

Metabolic Flux Analysis (MFA) based on isotope labeling experiments (ILEs) is a widely established tool for determining fluxes in metabolic pathways. Isotope labeling networks (ILNs) contain all essential information required to describe the flow of labeled material in an ILE. Whereas recent experimental progress paves the way for high-throughput MFA, large network investigations and exact statistical methods, these developments are still limited by the poor performance of computational routines used for the evaluation and design of ILEs. In this context, the global analysis of ILN topology turns out to be a clue for realizing large speedup factors in all required computational procedures.

Results

With a strong focus on the speedup of algorithms the topology of IL

SUBMITTER: Weitzel M 

PROVIDER: S-EPMC2233644 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature