Predicting gene ontology functions from protein's regional surface structures.

ABSTRACT:

Background

Annotation of protein functions is an important task in the post-genomic era. Most early approaches for this task exploit only the sequence or global structure information. However, protein surfaces are believed to be crucial to protein functions because they are the main interfaces to facilitate biological interactions. Recently, several databases related to structural surfaces, such as pockets and cavities, have been constructed with a comprehensive library of identified surface structures. For example, CASTp provides identification and measurements of surface accessible pockets as well as interior inaccessible cavities.

Results

A novel method was proposed to predict the Gene Ontology (GO) functions of proteins from the pocket similarity network, which is constr

SUBMITTER: Liu ZP 

PROVIDER: S-EPMC2233648 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature