Comparing patterns of natural selection across species using selective signatures.

ABSTRACT: Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what can be learned from individual genome-wide surveys. Toward this end, we show how variation in protein evolutionary rates, after correcting for genome-wide effects such as mutation rate and demographic factors, can be used to estimate the level and types of natural selection acting on genes across different species. We identify unusually rapidly and slowly evolving genes, relative to empirically derived genome-wide and gene family-specific background rates for 744 core protein families in 30 gamma-proteobacterial species. We describe the patte

SUBMITTER: Shapiro BJ 

PROVIDER: S-EPMC2233676 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature