Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy.

ABSTRACT: The widely observed dispensability of duplicate genes is typically interpreted to suggest that a proportion of the duplicate pairs are at least partially redundant in their functions, thus allowing for compensatory affects. However, because redundancy is expected to be evolutionarily short lived, there is currently debate on both the proportion of redundant duplicates and their functional importance. Here, we examined these compensatory interactions by relying on a genome wide data analysis, followed by experiments and literature mining in yeast. Our data, thus, strongly suggest that compensated duplicates are not randomly distributed within the protein interaction network but are rather strategically allocated to the most highly connected proteins. This design is appealing because it sugg

SUBMITTER: Kafri R 

PROVIDER: S-EPMC2234123 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature