Association of the matrix attachment region recognition signature with coding regions in Caenorhabditis elegans.

ABSTRACT:

Background

Matrix attachment regions (MAR) are the sites on genomic DNA that interact with the nuclear matrix. There is increasing evidence for the involvement of MAR in regulation of gene expression. The unsuitability of experimental detection of MAR for genome-wide analyses has led to the development of computational methods of detecting MAR. The MAR recognition signature (MRS) has been reported to be associated with a significant fraction of MAR in C. elegans and has also been found in MAR from a wide range of other eukaryotes. However the effectiveness of the MRS in specifically and sensitively identifying MAR remains unresolved.

Results

Using custom software, we have mapped the occurrence of MRS across the entire C. elegans genome. We find that MRS have a distinctive ch

SUBMITTER: Anthony A 

PROVIDER: S-EPMC2234258 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature