EFBAT: exact family-based association tests.

ABSTRACT:

Background

Family-based association tests are important tools for investigating genetic risk factors of complex diseases. These tests are especially valuable for being robust to population structure. We introduce a tool, EFBAT, which performs exact family-based tests of association for X-chromosome and autosomal biallelic markers.

Results

The program EFBAT extends a network algorithm previously applied to autosomal markers to include the X-chromosome and to perform tests of association under the null hypotheses "no association, no linkage" and "no association in the presence of linkage" under additive, dominant and recessive genetic models. These tests are valid regardless of patterns of missing familial data.

Conclusion

The general framework for performing exact fami

SUBMITTER: Schneiter K 

PROVIDER: S-EPMC2234422 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature