Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.

ABSTRACT:

Background

The signal transducer and activator of transcription 3 (STAT3) mediates gene expression in response to numerous growth factors and cytokines, playing an important role in many cellular processes. To better understand the molecular mechanisms by which Stat3 influences gene expression in the lung, the effect of pulmonary epithelial cell specific deletion of Stat3 on genome wide mRNA expression profiling was assessed. Differentially expressed genes were identified from Affymetrix Murine GeneChips analysis and subjected to gene ontology classification, promoter analysis, pathway mapping and literature mining.

Results

Total of 791 mRNAs were significantly increased and 314 mRNAs were decreased in response to the deletion of Stat3Delta/Delta in the lung. STAT is the mos

SUBMITTER: Xu Y 

PROVIDER: S-EPMC2234434 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature